RESUMO
The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation.
Assuntos
Técnicas de Tipagem Bacteriana/métodos , Tipagem Molecular/métodos , Filogenia , Polimorfismo de Nucleotídeo Único , Shigella sonnei/classificação , Shigella sonnei/genética , Disenteria Bacilar/epidemiologia , Disenteria Bacilar/microbiologia , Saúde Global , Humanos , Epidemiologia Molecular/métodos , Pandemias , Shigella sonnei/isolamento & purificação , Temperatura de TransiçãoRESUMO
To investigate global epidemiology of Shigella sonnei, we performed multilocus variable number tandem repeat analysis of 1,672 isolates obtained since 1943 from 50 countries on 5 continents and the Pacific region. Three major clonal groups were identified; 2 were globally spread. Type 18 and its derivatives have circulated worldwide in recent decades.
